Missouri Route 25

Route 25 Business
Route 25 Business
Location	Malden
Length	3.22 mi (5.18 km)

Route 25
Route 25
	Route 25 in red business route in blue
Route information
	Maintained by MoDOT
Length	86 mi (138 km)
Existed	1922–present
Major junctions
North end	I-55 BL / US 61 / Route 34 / Route 72 in Jackson
	Future I-57 / US 60 in Dexter; US 62 in McGuire;
South end	US 412 / Route 84 in Kennett
Location
Country	United States
State	Missouri
Highway system
	Missouri State Highway System; Interstate; US; State; Supplemental;

Route 25 is a highway in south-eastern Missouri. Its northern terminus is at Business Interstate 55/U.S. Route 61/Route 34 in Jackson. Its southern terminus is at U.S. Route 412/Route 84 in Kennett.

Route 25 was one of the original 1922 state highways. Its original northern terminus was at Route 9 in Festus. In 1926, with the creation of the U.S. Highway system, Route 9 from St. Louis to Hematite became part of U.S. Route 61, which was then routed down Route 25 to Jackson, moving Route 25's northern terminus to Jackson, too.

Until February 1981,^[1] when U.S. Route 412 was designated across the southernmost section, "the Bootheel", thus supplanting Route 25 south and west of Kennett, Route 25 passed Senath and Arbyrd, taking a sharp westward turn and heading across the St. Francis River and the Arkansas border, feeding westward to join the former Arkansas Highway 25 (now U.S. 412) toward Paragould, Arkansas. The old section of Route 25 south and west of Kennett now bears Missouri supplemental route designations.

Major intersections

County	Location	Destinations	Notes
Dunklin	Kennett	US 412 / Route 84 – Hayti, Rector, Southeast Missouri State University Kennett
	Kennett	Route E west (Ely Street) to Route 84 west
	White Oak	Route 153 north – Gideon
	Holcomb	Route 53 north – Campbell
	Clarkton	Route 162 east – Gideon
	McGuire	US 62 west – Campbell	south end of US 62 overlap
New Madrid		US 62 east / Route 25 Bus. north – Malden, Risco	north end of US 62 overlap
Dunklin	Malden	Route 25 Bus. south – Business District
Stoddard	Dexter	Route 114 east – Essex, Airport
		US 60 Bus. west	south end of US 60 Bus. overlap
		US 60 – Poplar Bluff, Sikeston	interchange; north end of US 60 Bus. overlap
		Route 91 south – Bell City	south end of Route 91 overlap
	Advance	Route 91 north – Marble Hill	north end of Route 91 overlap
Cape Girardeau	Blomeyer	Route 77 south / Route AB east to I-55 – Chaffee	roundabout
	Dutchtown	Route 74 east / Route A west – Whitewater, Cape Girardeau
	Jackson	I-55 BL / US 61 / Route 34 / Route 72 west / Great River Road – Fruitland, Millersville, Cape Girardeau
1.000 mi = 1.609 km; 1.000 km = 0.621 mi